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Feed ANFs-Protease Inhibitors
In the realm of animal nutrition, the presence of protease inhibitors (PIs) within feeds can hinder protein digestibility, which lead to detrimental physiological effects and stunted growth in animals. BioVenic offers solutions for detecting PIs in animal feed, evaluating their effects on animals, and aiding in the development of strategies to mitigate the adverse impacts of these antinutritional factors on animal nutrition.
Impacts of Dietary Protease Inhibitors on Animals
PIs are recognized for their ability to obstruct digestive enzymes primarily through competitive binding mechanisms. These inhibitors have been observed to enhance cholecystokinin secretion, consequently elevating the release of trypsin and chymotrypsin within the digestive system. The interference with protein digestibility caused by PIs can lead to an increased amount of undigested protein reaching the colon, where it becomes subject to fermentation by gut microbiota. This microbial breakdown of amino acids in the colon can yield potentially harmful byproducts. Certain protease inhibitors, such as ATIs, exhibit pro-inflammatory properties and have the capacity to induce non-celiac wheat sensitivity.
Table. 1 Impacts of dietary trypsin inhibitors (TI) on animals
| Animal types | Impacts |
|---|---|
| Pigs |
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| Chickens |
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| Shrimps |
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| Atlantic salmon |
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Feed Protease Inhibitors Solutions
Our comprehensive service platform seamlessly merges feed protease inhibitor analysis technology with a spectrum of in vitro and in vivo animal models, aiding animal nutrition researchers in crafting biodegradation methods and feed additives to mitigate the adverse impacts of protease inhibitors.
- Protease Inhibitors Analysis Solutions
The primary assay method employed to gauge protease inhibitor activity typically involves assessing the decline in protease functionality triggered by the presence of an inhibitor-containing extract. We offer Feed Anti-Nutritional Factor (ANF) Analysis services for analyzing the activity of diverse proteinases. Additionally, techniques like SDS-PAGE are used to delve into protein digestion processes, enabling the detection and characterization of digestive PIs present in protein-rich feed components. Our technological platform further facilitates the customization and development of novel assays tailored to pinpointing PIs as per the specific requirements of our clientele.
- Feed Additive Development for Protease Inhibitors
Through our assay platform and diverse animal models, our feed additive development solutions aim to cultivate supplements that counteract the impact of PIs on animal growth and well-being.
- Development of Biological Methods for Reducing Protease Inhibitors in Animal Feed
Several technologies, such as genetic modification, moist heat treatment, protein fractionation, and protease treatment, can be utilized to reduce PIs in processed plant proteins. Our approach revolves around utilizing biological techniques to diminish feed protease inhibitor levels and enhance feed quality. We assist in enzyme development and microorganism screening to facilitate feed processing via enzyme catalysis or microbial fermentation. By scrutinizing PIs, coupled with in vitro and in vivo animal studies, we explore the efficacy of biological processes in reducing these inhibitors.
- In Vitro Evaluation of Protein Digestibility
We provide animal in vitro digestion and fermentation models to delve into the impact of PIs on feed protein digestibility. These models aid in evaluating the effectiveness of feed additives or bioprocesses developed to combat PIs.
- Animal In Vivo Studies on Protease Inhibitors
Our array of animal in vivo models spans livestock, poultry, and companion animals. Leveraging our animal nutrition and metabolite analysis service and omics platform, we decipher the effects of protease inhibitor-laden feeds on animals. These models and technologies support the assessment of feed additives, fermentations, enzyme treatments, and other interventions aimed at addressing protease inhibitor concerns in animal feed.
Service Workflow of Feed Protease Inhibitors Solution
Why Choose Us?
Our technicians boast vast experience in animal nutrition and feed science research, swiftly aligning the perfect product or service with your research requisites.
We offer an array of in vivo and in vitro animal models to assess feed additives, bioprocessing, and comprehend the practical applications of feed protease inhibitor solutions.
Leveraging extensive internal and external research resources, we aid animal nutrition researchers in formulating feed additives and biological processes to combat anti-nutritional factors like protease inhibitors.
As your comprehensive provider of animal nutrition and feed solutions, BioVenic prioritizes customer needs. Our Feed ANFs-Protease Inhibitors solution empowers animal nutrition researchers to analyze feed protease inhibitor content. Through diverse animal models and advanced nutrition analysis techniques, we develop innovative feed additives and biological processes to mitigate the influence of PIs on animal nutrition. For those intrigued by our solutions, contact us for prompt and personalized assistance.