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Synthetic Carbohydrate-based Veterinary Vaccine Development
Most carbohydrate antigens in veterinary vaccines are obtained from microbial cultures. This origin presents challenges due to the intricate purification procedures and the presence of diverse components, adding complexity to the veterinary vaccine development process. To overcome these issues, BioVenic offers synthetic carbohydrate-based veterinary vaccine development services. Leveraging chemical synthesis, we assist in the development of pure and homogeneous vaccines, providing a safer and more effective alternative to veterinary vaccine design and development.
Our Services
Polysaccharide Synthesis
The biosynthesis of polysaccharides lacks a fixed template, is not directly encoded by genes, and cannot be obtained through gene expression as in the case of nucleic acids or proteins. BioVenic provides polysaccharide chemical synthesis services. Chemical synthesis is a crucial approach to obtaining polysaccharides with uniform structures. Antigenic polysaccharide components from bacteria often have the potential to stimulate the body to generate protective immune responses. In the process of polysaccharide synthesis, our team leverages their expertise to apply efficient glycosylation methods and sugar chain assembly strategies to complex polysaccharide antigens. This facilitates synthetic carbohydrate-based veterinary vaccine developments with high efficiency and quality.
Fig.1 Assembly of arabinogalactan 1 (an essential component of the Mycobacterium tuberculosis cell wall)1
Polysaccharide Purification
In the process of synthesizing polysaccharides using chemical methods, there are intermediates and byproducts present in the reaction system in addition to target polysaccharide antigens. The core of polysaccharide isolation and purification is to obtain polysaccharides with low dispersity and uniform charge, suitable for subsequent structural analysis and in-depth functional characterization. BioVenic provides polysaccharide purification services, allowing you to choose different purification methods based on the nature of the polysaccharide and the required purity level. We strive to meet all your requirements to complete the synthetic carbohydrate-based veterinary vaccine development.
Fractional Precipitation
Ultrafiltration
Gel Filtration Chromatography
Ion Exchange Chromatography
Synthetic Carbohydrate-based Veterinary Vaccine Development Services
| Compared to natural-derived vaccines, synthetic carbohydrate-based veterinary vaccines offer higher safety levels. However, synthetic polysaccharide antigens are inherently T-cell independent antigens. To enhance the immunogenicity of your veterinary vaccines, BioVenic offers formulation development tailored to your specific requirements, providing comprehensive adjuvant development services. | We conduct thorough in vitro and in vivo experiments to validate the effects of adjuvant addition and formulation optimization in terms of safety, immunogenicity, and effectiveness. For instance, BioVenic offers polysaccharide microarray assays for antibody binding assays, etc. | BioVenic provides quality control services, including purity analysis and structural analysis of polysaccharides, to maintain consistency throughout the synthesis process, ensuring you have a perfectly crafted vaccine. |
Why Choose Us?
A variety of glycosylation methods and assembly strategies to choose.
High-quality and efficient purification methods to facilitate synthetic carbohydrate-based veterinary vaccine development.
Exceptional formulation development patterns to enhance the immunogenicity of synthetic carbohydrate-based veterinary vaccine.
As a source of polysaccharide antigens, synthesis offers greater control and the potential to develop highly stable and consistent veterinary vaccines. Through our ongoing project collaborations, BioVenic has accumulated significant insights into the chemical synthesis of polysaccharide antigens. Similarly, we have established a platform for polysaccharide purification, providing you with a variety of methods to purify synthesized polysaccharides for use as the main component in veterinary vaccines. Contact us now to inquire further!
References
- Wu, Yong, et al. "Total synthesis of mycobacterial arabinogalactan containing 92 monosaccharide units." Nature communications 8.1 (2017): 14851.
- Mettu, Ravinder; et al. "Synthetic carbohydrate-based vaccines: challenges and opportunities." Journal of Biomedical Science 27 (2020): 1-22.