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Feed Probiotics-Bifidobacterium
Alongside Lactobacillus, Bifidobacterium offers numerous health benefits such as protection against pathogenic microbes, hypertension, inflammation, diabetes, and oxidative stress. These bacteria also contribute to microbiome modulation, immune modulation, and anti-cholesterolemic activity. BioVenic specializes in providing solutions for the development of Bifidobacterium as feed probiotics. Through our strain development expertise, rigorous safety and efficacy evaluation, and strict quality control measures, we offer a comprehensive platform for creating finished Bifidobacterium probiotic products suitable for various animal species.
Fig. 1 Bifidobacterium adolescentis1
Strain Development for Probiotic Bifidobacterium
- Bifidobacterium Isolation and Identification
We assist researchers in isolating and characterizing potential probiotic Bifidobacterium strains from diverse sample types like animal feces and intestinal contents. Using culture media formulation, biochemical and molecular biological identification techniques, we enable the detection of specific enzymes, determination of organic acids, sugar fermentation tests, and other related indicators for accurate identification.
- Genetic Study on Bifidobacterium
Our genetic study platform allows for the identification, analysis, and characterization of strains from Bifidobacterium spp., including their special characteristics, functions, and safety. We provide novel insights into the underlying mechanisms responsible for the probiotic effects of Bifidobacterium spp. strains.
Safety and Efficacy Assessment of Probiotic Bifidobacterium Strains
- Safety Assessment of Bifidobacterium Strains
We prioritize the safety aspect by verifying the absence of transferable antibiotic resistance genes or virulence factor genes in Bifidobacterium spp. strains, to prevent the development of antibiotic-resistant strains. Through our genetic studies, we confirm the absence of such genes, along with tests for bacterial resistance and phenotypic analysis of virulence factors, to ensure the safety of Bifidobacterium species as a probiotic.
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- In Vitro Efficacy Assessment of Bifidobacterium as Feed Probiotics
When probiotics are consumed orally, they may encounter harsh conditions in the upper GIT that can reduce their viability. Our in vitro efficacy assessment for Bifidobacterium simulates the gastrointestinal environment, allowing researchers to test the acid and bile salt resistance of probiotics and develop more effective formulations. We offer a range of in vitro methods to evaluate the adhesion ability, antagonism against intestinal pathogens, antioxidant capacity, and other properties of strains from Bifidobacterium spp.
- In Vivo Probiotic Effect Study of Bifidobacterium
To determine the use of probiotics as animal feed additives, optimal dosage, and compatibility with feed ingredients, in vivo experiments in specific animal species are essential. Our solution enables the exploration of probiotic applications in various animal models. Through biochemical analysis and omics studies of animal feed, metabolites, and products, we assess the impact of probiotic application on animal digestibility, growth performance, product quality, antioxidant capacity, and intestinal microbiota. These in vivo studies establish the foundation for understanding the probiotic effects of Bifidobacterium and its subsequent application.
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Probiotic Bifidobacterium Fermentation Solution
Our fermentation solution aids in studying Bifidobacterium fermentation by monitoring key indicators of interest. It helps determine the optimal values for each component of the probiotic fermentation medium and the fermentation conditions (e.g., inoculum, pH, temperature, time), providing researchers with efficient and cost-effective fermentation methods. Additionally, this solution serves as a reference for large-scale fermentation.
Quality Control of Probiotic Bifidobacterium
We prioritize quality control throughout all stages of Bifidobacterium probiotics development. Our solutions encompass strain testing, characterization, and product performance testing to ensure the safety and efficacy of the probiotics for use in animal feed additives.
Finished Products of Probiotic Bifidobacterium
We assist in developing various types of finished Bifidobacterium probiotic products for animal feed. Through in vivo and in vitro stability, safety, and efficacy tests across different forms (powder, tablets, liquid, microencapsulation), dosages, and shelf-lives, we help validate the performance of Bifidobacterium end-products as probiotics for animal feed.
Probiotic Effects of Bifidobacterium on Animals
Bifidobacterium demonstrates significant physiological and genetic features, including adhesion ability to epithelial cells and metabolism of host-derived glycans. Its application in animals yields benefits in performance improvement, gut health, and product quality, as depicted in Table 1.
Table. 1 Effects of some Bifidobacterium probiotics on animals
| Species | Animal species | Effects |
|---|---|---|
| B. animalis | Pigs | Promotes the growth of weaning piglets by improving intestinal development, enhancing antioxidant capacity, and modulating gut microbiota. |
| Laying hens | Improves laying performance and egg traits and can be a substitute for antibiotics. | |
| Dogs | Provides a tool for management of acute diarrhea in dogs. | |
| B. longum | Pigs | Continuous administration of bifidobacteria provides a beneficial effect on growth parameters. |
| B. thermophilum | Chicken | Enhances chicken resistance against Escherichia coli Infection. |
Feed Probiotic Bifidobacterium Development Workflow
Why Choose Us?
Integration of various in vivo and in vitro technique platforms allows for comprehensive characterization and evaluation of different Bifidobacterium strains as feed additives.
Our diverse animal models accurately reflect the effects of Bifidobacterium probiotics in different animal species, growth stages, and nutritional requirements, facilitating the development of species-specific products.
Our professional research platform covers multiple aspects of Bifidobacterium feed additive development, enabling a holistic understanding of probiotic properties and application effects.
BioVenic's experienced staff possesses extensive expertise in probiotic development, animal models, fermentation, and more, ensuring effective support throughout the Bifidobacterium probiotics development process. If you require assistance with Bifidobacterium probiotic strain development, safety and efficacy evaluation, in vivo and in vitro probiotic effect studies, fermentation optimization, quality control, or end-product development, please contact us. We would be delighted to learn about your research plans and provide the necessary assistance.
Reference
- From Wikipedia: By Y tambe, CC BY-SA 3.0, https://upload.wikimedia.org/wikipedia/commons/3/35/Bifidobacterium_adolescentis_Gram.jpg.