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Feed Probiotics-Lactobacillus
Lactobacillus is a genus of gram-positive, aerotolerant anaerobes or microaerophilic bacteria. These rod-shaped bacteria do not form spores and are an essential part of the human and animal microbiota at various body sites. BioVenic provides advanced solutions for the development of Lactobacillus species as probiotics for animal feed. With our integrated approach to strain development, safety and efficacy assessment, and specialized fermentation solutions, we offer our customers a streamlined process to develop high-quality feed Lactobacillus probiotics products.
Fig. 1 Lactobacillus johnsonii1
Strain Development for Probiotic Lactobacillus
- Lactobacillus Isolation and Identification
We conduct extensive screening of bacterial strains from food or animals to help researchers develop new Lactobacillus strains with excellent performance or probiotic potential. Our solutions include selective cultivation, microbiological identification, biochemical testing, and assessment of specific substrate hydrolytic ability among other techniques.
- Genetic Research on Lactobacillus
Our genetic research platform provides various solutions for Lactobacillus species with probiotic potential. We use technologies such as strain identification by 16S rRNA sequencing, whole-genome sequencing and analysis, gene expression studies, and gene editing to identify potential Lactobacillus species, evaluate their probiotic potential, and modify them for better strains.
Safety and Efficacy Assessment of Probiotic Lactobacillus
- Safety Assessment of Lactobacillus
Given the genetic diversity among different strains of Lactobacillus, it's crucial to evaluate the safety of specific strains during probiotic development. We offer techniques to detect virulence-associated genes, antibiotic resistance genes, and genes related to substance harmful production using PCR, sequencing, and bioinformatics analysis. We also analyze harmful enzymes or virulence factors produced in in vitro cultures.
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- In Vitro Efficacy Assessment of Lactobacillus as Feed Probiotics
Our in vitro research platform studies the tolerance of Lactobacillus to acid, bile salt, and simulated gastrointestinal fluid. We also evaluate various efficacy parameters like adhesion ability, antioxidant activity, reducing ability, and anti-foodborne pathogen activity. Experimental designs can be customized based on specific research needs.
- In Vivo Probiotic Effect Study of Lactobacillus
We use in vivo models of farm animals and companion animals to study the safety and probiotic effects of Lactobacillus as an animal feed additive. Our molecular assays and advanced omics technology help researchers explore the mechanism of action of Lactobacillus in animals and discover biomarkers related to its probiotic performance.
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Probiotic Lactobacillus Fermentation Solution
Our Probiotic Lactobacillus Fermentation Solution focuses on developing a practical medium and optimal fermentation process for cost-effective Lactobacillus fermentation. By optimizing culture media and conditions, monitoring cell growth, and substrate consumption kinetics, we assist in developing fermentation methods with good stability and repeatability suitable for producing Lactobacillus for feed probiotics.
Lactobacillus Probiotics Development
We ensure the quality of the final product through viability and purity control at all stages of Lactobacillus probiotic development, including strain development, in vivo and in vitro testing, and fermentation research. We offer a range of probiotic Lactobacillus development service in various forms, such as solid, lyophilized powders, and microcapsules. We evaluate the product through stability testing and in vivo and in vitro efficacy studies, helping researchers develop probiotic Lactobacillus products suitable for specific animals and feeding strategies.
Probiotic Effects of Lactobacillus on Animals
Lactobacillus species have been extensively studied as feed additives for animals, showing positive effects on growth performance, immunity improvement, harmful bacteria reduction, and quality/yield enhancement of animal products. These bacteria also enhance nutrient digestion by producing active dietary enzymes like protease, amylase, lipase, phytase, and protease.
Table. 1 Effects of some Lactobacillus probiotics on animals2
| Species | Type of breeding | Effect |
|---|---|---|
| L. fermentum | Piglets |
|
| Grower-finisher pigs | Enhance superoxide dismutase, glutathione peroxidase, and catalase. | |
| Poultry | Regulate the intestinal mucosal immune response and ameliorate inflammation caused by Clostridium perfringens. | |
| L. sobrius | Piglets | Limit intestinal colonization by pathogenic E. coli. |
| L. salivarius | Swine and poultry | Improve the immune status and reduce colonization by pathogenic bacteria in swine and poultry. |
| L. rhamnosus | Fish | Reduce mortality in Rainbow trout fish affected by A. salmonocida and in Tilapia affected by Edwardsiella tarda. |
| L. reuteri | Piglets | Beneficial effects on the expression of tight Junction proteins in newborn piglets (L. reuteri I5007). |
| L. plantarum | Fish | Reduce mortality in Rainbow trout fish affected by Lc. Garvieae. |
| Grower-finisher pigs | Enhance superoxide dismutase, glutathione peroxidase and catalase. | |
| L. acidophilus | Chicken |
|
| Piglets |
|
|
| L. amylovorus | Pigs and piglets |
|
| L. paracasei | Piglets | limit intestinal colonization by pathogenic E. coli. |
| L. pentosus | Fish | Improve immune system and survival rate of Japanesse eel fish affected by Edwardsiella tarda. |
| L. brevis | Fish | Reduce mortality of Tilapia affected by A. hydrophilia. |
| L. casei | Piglets |
|
| Lc. lactis | Fish | Activate the innate immune system of Olive flounder fish and protect against pathogen infections. |
Feed Probiotic Lactobacillus Development Workflow
Why Choose Us?
Our comprehensive research methods combining genetics, molecular biology, and microbiology enable us to provide valuable insights for the development of Lactobacillus as feed probiotics.
Our platform conducts animal experiments to evaluate the safety and efficacy of potential probiotic Lactobacillus, paving the way for their application as feed additives.
With backgrounds in animal nutrition, microbiology, and fermentation engineering, our research team quickly understands your needs and provides feasible solutions.
By choosing us, you gain not only a probiotic development solution but also a research partner. BioVenic offers a range of solutions for strain development, safety and efficacy assessment, fermentation, and finished product development. Our goal is to help researchers develop Lactobacillus probiotics suitable for specific animal species. If you require the development of feed Lactobacillus probiotic additives, please contact us with your research needs, and we would be delighted to collaborate with you.
References
- From Wikipedia: By Oregon State University, CC BY-SA 2.0. Without modification. https://en.wikipedia.org/wiki/File:Lacto_johnson.jpg.
- Arsène, Mbarga M J et al. "The use of probiotics in animal feeding for safe production and as potential alternatives to antibiotics." Veterinary world vol. 14,2 (2021): 319-328. Under Open Access license CC BY 4.0. Quoted part of the original text.