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Feed Probiotics-Streptococcus

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Strain Development Safety and Efficacy Fermentation Solution Probiotics Development Probiotic Effects Workflow Why Choose Us?

Streptococcus is a type of gram-positive coccus or spherical bacteria that commonly form pairs or chains, often appearing bent or twisted. Most streptococci are negative for oxidase and catalase, and many can survive with or without oxygen. BioVenic offers a comprehensive solution for animal nutrition researchers involved in developing Streptococcus-based probiotics for animal feed. This solution encompasses various aspects such as strain development, safety and efficacy evaluation, Streptococcus fermentation solutions, quality control measures, and finished product development.

Fig. 1 Photomicrographs of Streptococcus thermophilus ACA-DC 2 (Alexandraki, et al., 2017)Fig. 1 Photomicrographs of Streptococcus thermophilus ACA-DC 21

Strain Development for Probiotic Streptococcus

  • Streptococcus Isolation and Identification

Through the use of media development, biochemical and enzyme assays, we can isolate potential probiotic strains of Streptococcus and conduct preliminary characterization. By employing techniques like qPCR, 16S rRNA sequencing, and other methods, we can further analyze and characterize the Streptococcus strains. Additionally, based on the genomic information obtained, we offer developing service of qPCR kits and other assays to simplify the identification process of Streptococcus strains in samples.

  • Genetic Study on Streptococcus

Researchers can utilize our genetic research platform to access the genomic information of Streptococcus strains and investigate genes associated with beneficial properties. These may include genes related to gastrointestinal condition tolerance, intestinal adhesion and colonization, synthesis pathways of compounds beneficial to the host, antioxidant enzymes, and genes for producing beneficial metabolites. Furthermore, genetic studies can help determine the presence of antibiotic resistance genes and virulence genes, aiding in the selection of relatively safe strains of Streptococcus.

Safety and Efficacy Assessment of Probiotic Streptococcus Strains

  • Safety Assessment of Streptococcus Strains

As the Streptococcus genus comprises both commensal and pathogenic species, ensuring safety is crucial when introducing new strains as animal feed additives. To address this, we offer a range of molecular and phenotypic methodologies to detect antibiotic resistance, virulence determinants, and other factors associated with the safety of Streptococcus strains. These assessments help to ensure the safe use of Streptococcus-based probiotics in animal nutrition research.

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  • In Vitro Efficacy Assessment of Streptococcus as Feed Probiotics

Our comprehensive in vitro evaluation of Streptococcus as feed probiotics includes assessing resistance to simulated gastrointestinal conditions, analyzing adhesion potential, measuring antioxidant activity, and conducting various other assays. These in vitro methods enable researchers to identify promising Streptococcus strains for further development into feed probiotics.

  • In Vivo Probiotic Effect Study of Streptococcus

To confirm the safety and efficacy of Streptococcus as a probiotic in animals of diverse ages, breeds, and physiological states, we offer a range of in vivo research solutions. Through comparative experiments, we assist researchers in exploring the impact of Streptococcus probiotics on animal health indicators, growth performance, immune function, reproductive performance, antioxidant capacity, and more. These studies also help determine optimal dosing, compatibility with other feed additives, and expand the application of Streptococcus probiotics.

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Probiotic Streptococcus Fermentation Solution

To improve the production of probiotic Streptococcus and related products for animals, it is essential to understand the fermentation characteristics of Streptococcus strains. We provide fermentation solutions for optimizing fermentation processes, analyzing fermentation metabolites, and monitoring the fermentation progress. These solutions aid researchers in developing appropriate fermentation protocols to increase the production of probiotic Streptococcus and enhance the yield of probiotic molecules, including antibacterial substances.

Streptococcus Probiotics Development

Ensuring the quality of Streptococcus as feed additives is a paramount concern for both animal probiotic researchers and animal owners. As part of the development of probiotic Streptococcus, we offer comprehensive quality control solutions, including the quality control of probiotic Streptococcus strains, probiotic cultures, and finished products. Our integrated platforms not only provide solutions for developing various forms of probiotic Streptococcus products but also offer in vitro and in vivo research solutions to analyze different Streptococcus feed probiotics. Our service enables us to develop superior types of probiotic Streptococcus products tailored to specific animals.

Probiotic Effects of Streptococcus on Animals

Although Streptococcus thermophilus, the only species within the genus, has obtained Generally Recognized as Safe (GRAS) status, the use of Streptococcus as a probiotic additive in animal feed is still limited. Research on the safety and efficacy of different Streptococcus strains remains a major concern. The following table presents the probiotic effects of various Streptococcus species on animals.

Table. 1 Effects of some Streptococcus probiotics on animals

Species Animal Species Effects
Streptococcus thermophilus Pigs
  • Exopolysaccharides from Streptococcus thermophilus modulates the antiviral immune response in Porcine Intestinal Epitheliocytes (PIE) cells.
  • A feed additive containing Streptococcus thermophilus showed potential to increase the body weight of suckling piglets.
Streptococcus salivarius Dogs Can be expected to exert a mouth odor-suppressing effect in dogs.
Streptococcus phocae Shrimp Bacterial probionts Streptococcus phocae and Enterococcus faecium isolated from shrimp and brackish water fish has potential applications for controlling pathogenic vibriosis in shrimp culture.
Streptomyces coelicolor Chicken Both Lactobacillus reuteri and Streptomyces coelicolor have beneficial effects on broiler chickens as it pertains to FC, BWG, FCR, carcass.

Feed Probiotic Streptococcus Development Workflow

Fig. 2 Feed probiotic Streptococcus development workflow (BioVenic Original)

Why Choose Us?

Our team consists of experts with research backgrounds in microbiology, animal nutrition, animal physiology, etc., allowing us to comprehend your research needs from multiple perspectives.

Our technology platform seamlessly integrates animal testing, in vitro experimentation, biochemical analysis, omics research, and other platforms, enabling comprehensive probiotic Streptococcus development research.

We specialize in the development of animal feed additive products and possess the expertise to formulate appropriate Streptococcus probiotics for different animal species, ages, and physiological conditions.

As a committed participant in the field of animal nutrition research, BioVenic prioritizes the latest scientific discoveries and strives to develop feed Streptococcus probiotics suitable for animals. Our development solutions encompass strain development, safety and efficacy studies, fermentation optimization, end-product development, and more. If you are interested in our services, please feel free to contact us.

Reference

  1. Alexandraki, Voula, et al. "The complete genome sequence of the yogurt isolate Streptococcus thermophilus ACA-DC 2." Standards in Genomic Sciences 12 (2017): 1-10. Under Open Access license CC BY 4.0, without modification.
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