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Veterinary Virus SNP Genotyping
Single nucleotide polymorphisms (SNPs) are variations in DNA sequences caused by single nucleotide changes in the genome. These variations include base substitutions, insertions, deletions, and rearrangements. In the veterinary virus genome, SNP sites are abundant and often correlate with phenotypic differences, such as changes in drug susceptibility. BioVenic has accumulated extensive experience in SNP site detection, boasting not only advanced instrumentation but also a variety of methods based on different technologies. We are committed to providing comprehensive and custom veterinary virus SNP genotyping services, empowering our clients in their research on virus diagnosis, evolution, immunology, and more.
Featured Veterinary Virus SNP Genotyping Services
Our SNP genotyping services are primarily focused on veterinary DNA and RNA viruses with reference sequences, such as avian influenza viruses, coronaviruses, rotaviruses, etc. We accept samples related to livestock animals (like cattle and sheep), companion animals (like dogs and cats), poultry (like chickens and ducks), as well as aquaculture animals (like fish and shrimp). These samples include tissues and other biological fluids. Additionally, we welcome clients to submit already extracted genomic material of animal viruses. For clients interested in specific SNPs, we offer primer and probe design services to amplify the DNA region containing the targeted SNP. To meet various client needs, we provide custom SNP genotyping services based on different technologies.
Real-time PCR-based SNP Genotyping
When clients are interested in a small number of SNP loci and have a limited sample, our real-time PCR-based SNP genotyping service is a suitable choice. Using fluorescence-labeled probes, we rapidly and sensitively assist clients in detecting the presence of SNPs and conducting gene association analyses.
TaqMan-based SNP Genotyping
For large-scale SNP detection involving multiple SNPs simultaneously, our TaqMan-based SNP genotyping service is available. We design dual-fluorescence probes (TaqMan probes) specifically for SNP typing, ensuring base matching with the targeted SNP locus. SNP identification is achieved through changes in fluorescence signals.
NGS-based SNP Genotyping
To address the need for simultaneous detection of a large number of SNPs or SNP detection across the entire genome of a veterinary virus, we provide NGS-based SNP genotyping services. Various NGS sequencing technologies, including whole genome sequencing (WGS), targeted sequencing, whole exome sequencing (WES), and RNA sequencing (RNA-Seq), enable high-throughput SNP detection.
Microarray-based SNP Genotyping
Utilizing the principle of base complementarity hybridization, we offer custom microarray-based SNP genotyping services. We design probe panels for SNPs of customer interest, label DNA probes with isotopes or fluorescent markers, and integrate millions of probes onto a chip. This customized service aids clients in comprehensive veterinary virus genome association studies.
Veterinary Virus SNP Genotyping Workflow
Applications
Veterinary Virus Subtype Identification
SNP genotyping assists in identifying distinct viral subtypes, enabling clients to delve into the genetic variations, transmission pathways, and epidemiological characteristics of veterinary viruses.
Veterinary Virus Evolution and Evolutionary Analysis
SNP genotyping provides clients with insights into the evolution and evolutionary processes of the veterinary virus, aiding in understanding how the virus adapts to new hosts and other changes.
Vaccine Development
By analyzing SNPs among viral strains, a better understanding of the veterinary virus's variability is gained, helping clients select more representative viral vaccine strains and enhancing vaccine coverage and efficacy.
Veterinary Virus Drug Resistance Analysis
Analyzing SNPs in the viral genome assists clients in studying the effectiveness and drug resistance of antiviral medications, crucial for devising more effective treatment strategies.
Veterinary Virus Origin Tracing
SNP genotyping allows for tracing the origin and transmission paths of the veterinary virus. This plays a pivotal role in disease outbreak investigations, aiding in the timely interruption of virus transmission.
Immunological Research
The presence of SNPs in the viral genome may influence the veterinary virus's immune evasion capability. SNP genotyping provides a comprehensive understanding of the interaction between the virus and the host immune system.
Why Choose Us?
- Multi-Technology Integration: We integrate PCR, NGS, and chip technologies, leveraging their respective advantages to ensure a comprehensive virus SNP genotyping service for our clients.
- High Throughput and High Resolution: Through the efficient use of NGS and chip technologies, we can conduct SNP analysis at the whole-genome level, providing high-resolution results that reveal subtle genetic differences in viruses for our clients.
- Expert Team: Our sequencing team comprises experienced professionals dedicated to delivering high-quality virus SNP genotyping services, saving clients valuable research time.
SNP genotyping serves as a powerful tool in animal virus research, assisting clients in gaining a profound understanding of the genetic diversity, evolutionary dynamics, and mechanisms of interaction with hosts in viruses. This is crucial for developing veterinary diagnostics, vaccine research, and the discovery of therapeutic drugs. BioVenic offers clients a comprehensive and efficient animal virus SNP genotyping service. If you are interested in our services, please feel free to contact us at any time.
References
- Harper, Helen, et al. "Detecting SARS-CoV-2 variants with SNP genotyping." PloS one 16.2 (2021): e0243185.
- Rollin, Johan, et al. "Detection of single nucleotide polymorphisms in virus genomes assembled from high-throughput sequencing data: large-scale performance testing of sequence analysis strategies." PeerJ 11 (2023): e15816.