This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Animal Bile Acids Metabolomics Analysis
BioVenic customizes targeted metabolomics analysis services for bile acids metabolites in animals and provides researchers around the world with a comprehensive analysis of the metabolomics information involved. We utilize high-throughput detection methods to facilitate a range of research and development projects focused on investigating the physiological functions of bile acids, metabolic pathways, various modification processes, and biomarkers associated with health assessment and disease.
Background
Bile acids are the main components of bile that are synthesized by the liver using cholesterol and stored in the gallbladder. Bile acids play an important role in the digestive process. They are released into the intestines to emulsify dietary fats according to the animal's food intake, thereby promoting the absorption of lipids and fat-soluble vitamins in the animal's body. Bile acids are also modified by the microbial flora in the gastrointestinal tract and are dissociated by the action of bile salt hydrolase. This process generates free primary bile acids, which are then further dehydroxylated to produce various secondary bile acids. Bile acids are essential substances for animal fat metabolism and play important physiological roles, such as emulsifying fat, producing bile, and preventing gallstones. It not only has important physiological functions, but it is also a biomarker for measuring the health of the liver, gallbladder, and the entire body, as well as a variety of related diseases.
Fig.1 Schematic Overview of Bile Acid Metabolism in Organisms. 1
Animal Bile Acid Metabolomics Services
BioVenic has developed efficient and sensitive targeted metabolomic analysis solutions for bile acids in animal samples, and custom-designed project plans according to customers' specific needs. With our advanced UPLC-MRM/MS, LC-MS, and other detection platforms, we have successfully achieved absolute quantification of dozens of bile acid mixtures in animal blood, urine, feces, and amniotic fluid. The complete set of one-stop services includes animal sample collection and initial extraction of bile acid components, instrument detection, data statistical analysis and absolute quantification of target metabolites. We support full customization end-to-end. Of course, if you encounter any unsolvable problems in a specific area, BioVenic's team of experts will create a customized experimental plan for you. Our professional technicians will then carry out the plan, effectively overcoming any technical obstacles you may be facing.
Flow Chart of Animal Targeted Metabolomics Analysis Service
It is worth noting that the composition and modification of bile acids are closely related to the microbial flora of the gastrointestinal tract. BioVenic also provides the following customized services for microbial flora:
Types of Animal Bile Acids
| Classification standards | By Source | By Structure |
|---|---|---|
| Bile Acids | Primary bile acids: Cholic acid and chenodeoxycholic acid. | Free bile acids: Cholic acid, deoxycholic acid, chenodeoxycholic acid and small amounts of lithocholic acid. |
| Secondary bile acids: Deoxycholic acid and lithocholic acid. | Conjugated bile acids: Glycocholic acid, glycochenodeoxycholic acid, taurocholic acid and taurochenodeoxycholic acid, etc. |
Why Choose Us?
An integrated system for isolation, characterization, identification, and quantification of animal bile acid metabolomics.
Outstanding robustness and reproducibility of bile acid metabolite data.
Design customized, reliable and efficient solutions based on customers' individual needs.
BioVenic provides clients with a comprehensive analysis of animal bile acid metabolism. For scientific research purposes such as determining bile acid synthesis and metabolism, cholesterol analysis, and analyzing various types of bile acids, our professional R&D team offers dependable experimental solutions and precise quantification of target metabolites. Our sample processing and storage procedures are standardized and standardized to strictly ensure sample integrity and the reliability of the entire metabolic detection analysis. Please contact us to customize our solution for bile acid quantification.
Reference
- Pushpass, Rose-Anna G., et al. "Circulating bile acids as a link between the gut microbiota and cardiovascular health: Impact of prebiotics, probiotics and polyphenol-rich foods." Nutrition Research Reviews 35.2 (2022): 161-180.