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Feed Prebiotics-Malto-Oligosaccharides (MOS)
Malto-oligosaccharide (MOS) is a type of saccharide where a glucose molecule forms branched bonds (α-1,4) with a degree of polymerization (DP) ranging from 2 to 9. It functions as an oligosaccharide that promotes health in both humans and animals. At BioVenic, we offer a range of solutions for MOS production and characterization, as well as evaluation of its effects in vitro and in vivo. We also provide services for mechanism study, finished product development, and evaluation.
Production and Characterization of MOS Prebiotics
- Production of MOS Prebiotics
In industrial settings, MOS is synthesized from starch using a group of debranching enzymes known as malto-oligosaccharides forming amylases (MFAses). Our integrated platform can enhance the enzymatic properties of MFAses, leading to improved MOS production yield. Additionally, by controlling production conditions, we can further enhance MOS yield.
- Characterization of MOS Prebiotics
Our analysis platform employs advanced technologies to detect, quantify, and characterize MOS ingredients in feed. Commonly used techniques include HPAEC-PAD, MS detection (MSD), matrix-assisted laser desorption ionization (MALDI), time-of-flight mass spectrometry (TOF-MS), and Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS). These methods provide information on MOS concentration, for instance, degree of polymerization (DP), molecular weight, peak purity, and partial structure composition.
In Vitro Study of MOS as Animal Feed Prebiotics
- In Vitro Prebiotic Efficacy of MOS
MOS exerts a prebiotic effect on animals by regulating the growth of gastrointestinal probiotics. Utilizing MOS as a substrate in specific media, we can conduct in vitro prebiotic efficacy tests to explore its proliferation effect on probiotics such as Bifidobacterium spp. These experiments also provide insights for the development of MOS-containing synbiotics.
- In Vitro Digestion of Prebiotic GOS
We offer an in vitro digestion model that simulates the pH, digestive enzymes, and conditions of animal saliva, gastric juice, and intestinal juice. This model allows researchers to understand the digestibility of different MOS components in various parts of the digestive tract and the changes in MOS sugar composition before and after in vitro digestion.
- In Vitro Fermentation of Prebiotic MOS
Using our in vitro fermentation model, researchers can investigate the changes in microbiota, microbial metabolites (e.g., short-chain fatty acids), and other processes by utilizing animal feces or digesta microorganisms as the inoculum and MOS as the fermentation substrate. Various analytical methods are available to explore microbial diversity, abundance, and changes in microbial composition.
In Vivo Evaluation of MOS in Animals
Our wide range of animal models helps nutrition researchers evaluate the effects of MOS in vivo. By adding MOS of different doses and compositions to animal feed, researchers can explore the optimal dosage and application effects of MOS in different animals. Evaluation parameters include growth performance, immune indicators, intestinal health indicators, intestinal microbial metabolites, etc. These in vivo studies provide valuable data support for subsequent product development.
Mechanism Study of Feed Prebiotics MOS
With our diverse assay technologies, such as immunoassays, chromatography, and high-throughput omics methods, we support studies related to the mechanism of action of MOS in animals. Additionally, we offer assay development services to explore new biomarkers related to MOS.
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Feed MOS Prebiotics Development
Our solutions aid researchers in developing MOS prebiotic finished products in various forms for animal feed additives. Our research focuses on evaluating the effects of MOS on animals, determining appropriate dosages, and assessing compatibility with other prebiotics or probiotics. We also verify the content and purity of prebiotic MOS through various analysis methods.
Applications of MOS as Feed Prebiotics
MOS, as a functional oligosaccharide, serves as the primary substrate for intestinal α-glucosidases derived from enterocytes. This provides continuous and steady energy after entering the small intestine. Some application effects of MOS in animal feed are shown in Table. 1.
Table. 1 Application effects of MOS in animal feed
| Animal types | Effects |
|---|---|
| Pigs |
|
| Poultry |
|
| Dogs |
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Development Workflow of Feed Prebiotics MOS
Why Choose Us?
Abundant Resources
We possess extensive internal and external resources to provide strain and enzyme optimization solutions for MOS production, helping increase the yield of prebiotic MOS suitable for animal feed.
Integrated Research
Our solution integrates in vivo and in vitro animal research models to study the prebiotic properties of MOS from the perspective of digestion and fermentation.
Wide Range of Assays
We offer various assays to detect animal physiological and biochemical indicators, fermentation products, and more aspects related to the prebiotic performance of MOS. Moreover, we provide assay development services.
Our research team closely monitors the latest progress in feed prebiotic MOS studies. If you have research requirements in the areas of MOS production, characterization, in vitro prebiotic efficacy, digestive and absorption properties, in vivo application effects, mechanism studies, product development, or validation of feed MOS prebiotics, please contact us with your research needs. BioVenic's staff will provide timely feedback and assistance.