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Feed Prebiotics-Polysaccharides
Polysaccharides, which are complex carbohydrates formed by the condensation of at least 10 monosaccharides and connected by glycosidic bonds like α-1,4-, β-1,4-, and α-1,6-, play a significant role in various biological processes. They can be classified into different categories based on their source, including microbial polysaccharides, seaweed polysaccharides, higher animal polysaccharides, and higher plant polysaccharides. In recent years, there has been a growing interest in studying the prebiotic effects of polysaccharides. At BioVenic, we specialize in providing solutions for the development of prebiotic polysaccharides for animals. Our comprehensive range of services includes production and characterization, in vitro and in vivo studies, mechanism research, and finished product development and evaluation.
Fig. 1 Classification of natural polysaccharides based on their source1,2
Production and Characterization of Prebiotic Polysaccharides
- Production of Prebiotic Polysaccharides
we assist in the production of prebiotic polysaccharides by optimizing the extraction and separation processes based on their specific sources. We utilize efficient enzymes and study the optimal compatibility to enhance the enzymatic extraction of prebiotic polysaccharides.
- Characterization of Prebiotic Polysaccharides
Characterizing polysaccharides is crucial to understand their biological activity. Our advanced detection platform offers various analytical methods such as NMR analysis, HPLC, atomic force microscopy, and mass spectrometry. These techniques facilitate qualitative and quantitative analysis, structure determination, purity assessment, molecular weight analysis, and evaluation of monosaccharide composition.
In Vitro Study of Polysaccharides as Animal Feed Prebiotics
- In Vitro Prebiotic Efficacy of Polysaccharides
In vitro studies enable us to assess the prebiotic efficacy of polysaccharides as animal feed additives. By utilizing polysaccharides as a carbon source and studying their impact on probiotics strain growth, enzyme activity, and in vitro anaerobic fermentation, we can identify optimal prebiotics for specific probiotics. Moreover, we investigate the differences in the prebiotic efficacy of various polysaccharides and aid in the development of synbiotics for animals.
- In Vitro Digestion of Prebiotic Polysaccharides
In vitro digestion models based on the salivary and gastrointestinal environments of different animals allow us to evaluate the digestion of prebiotic polysaccharides in a controlled system. Through in vitro digestion studies and analysis of digestion products such as molecular weight changes, reducing sugar content and free monosaccharides, we can determine the digestibility of polysaccharides.
- In Vitro Fermentation of Prebiotic Polysaccharides
Additionally, our in vitro fermentation models provide insights into how polysaccharides interact with the gut microbiota. By investigating the effects of polysaccharides on animal gastrointestinal or fecal microbiota, we gain valuable information regarding their potential as animal prebiotics. These studies help in exploring the production of metabolites, particularly short-chain fatty acids (SCFAs), which play a vital role in animal health.
In Vivo Evaluation of Polysaccharides in Animals
To evaluate the application of polysaccharides, we conduct in vivo trials on animals of diverse species, ages, and health conditions. These trials enable us to assess the effectiveness of polysaccharides in promoting animal growth, antioxidant effects, immune system enhancement, and their impact on the microbiota and metabolites. By understanding the in vivo effects, we can develop combined prebiotic and synbiotic products.
Mechanism Study of Feed Prebiotic Polysaccharides
Understanding the mechanistic aspects of feed prebiotic polysaccharides is critical for their optimal application. Using our in vivo animal research platform and a variety of assays and analytical methods, we investigate the structural and functional changes in animal microbes and metabolites. By synthesizing structural information of polysaccharides and studying changes in microbial composition and animal metabolism, we contribute to a deeper understanding of the mechanisms of specific prebiotic polysaccharides.
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Prebiotic Polysaccharides Development
Prebiotic polysaccharides can be developed not only as feed additive products alone, but also as symbiotic products together with various probiotics. In addition, prebiotic polysaccharides can also be used as microencapsulation wall material for probiotics. For different forms and efficacy of products of prebiotic polysaccharides, we are able to help solve problems in the product development process through analysis, safety and efficacy evaluation in various models.
Applications of Polysaccharides in Animal Feed
Polysaccharides find diverse applications in animal feed due to their various beneficial properties, such as anti-inflammatory, immune regulation, glycolipid regulation, and anti-cancer effects. They also demonstrate potential prebiotic activity in animals. The application effects of some polysaccharides in animal feed are shown in Table. 1.
Table. 1 Application effects of polysaccharides in animal feed
| Polysaccharides | Animal Types | Effects |
|---|---|---|
| Seaweed polysaccharides | Pigs | Potential to enhance gut health, boost immunity, increase productivity, and reduce antibiotic usage in pigs. |
| Mushroom polysaccharides | Pigs | Extracellular polysaccharides of G. lucidum have improved immune function and meat quality. They could serve as a potential feed additive for enhancing animal health and meat quality. |
| Mushroom and herb polysaccharides | Chickens | Modified intestinal microbiota in diseased chickens. |
| Beta-glucans | Poultry | Capable of altering the immune response in poultry. |
| Pectin | Pigs | Shaped the colonic microbiota from a Lactobacillus-dominating flora to a Prevotella-dominating community, potentially promoting health effects. |
| Pullulan | Dogs | May have beneficial effects on the microbial ecology of dogs. |
| Glucomannan | Pigs | Dietary supplementation demonstrated protective effects against AFB1 and T-2 toxin immunotoxicity during a vaccinal protocol. |
| Arabinogalactan | Oncorhynchus mykiss | Dietary supplement with dihydroquercetin and arabinogalactan is beneficial for fish tolerance to environmental stressors and the lipid composition of fish fillets for human consumption. |
| Chitosan | Poultry and pigs | Hold immunomodulatory, anti-oxidative, antimicrobial, and hypocholesterolemic properties, often resulting in improved growth performance (body weight gain/feed conversion ratio) in young animals. |
Development Workflow of Feed Prebiotic Polysaccharides
Why Choose Us?
Extensive analytical techniques to characterize polysaccharides and determine crucial details like purity and molecular weight.
Our in vivo and in vitro animal models enable comprehensive studies on applications and mechanisms of action.
Comprehensive solutions for developing polysaccharide-based probiotic products efficiently address research challenges.
Whether sourced from plants, fungi, or other origins, polysaccharides hold significant potential for animal feed prebiotics. BioVenic's integrated approach for developing probiotic polysaccharides encompasses production, characterization, evaluation, and product development. Leveraging internal and external resources, we are dedicated to efficiently supporting your needs. Contact us for tailored animal feed additive solutions involving prebiotic polysaccharides.
References
- Image retrieved from Figure 2 "Classification of natural polysaccharides based on their source." Ben Akacha et al., 2024, used under [CC BY 4.0]. Without modification.
- Ben Akacha, Boutheina, et al. "Recent advances in the incorporation of polysaccharides with antioxidant and antibacterial functions to preserve the quality and shelf life of meat products." Foods 12.8 (2023): 1647.