CRISPR Knockout in Precision Animal Breeding

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CRISPR Knockout in Precision Animal Breeding

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The CRISPR system has become a widely used, efficient and convenient gene editing tool. BioVenic, relying on mature and comprehensive genome editing technology, a variety of tool carriers and expertise in transfection methods for farmed animals, offers personalized gene knockout services based on the CRISPR system, which can be applied to the scientific research in animal precision breeding. We are committed to solving all the difficulties you encounter in the knockout of target genes, making genome editing research easier.

Fig.1 Fig.1 Schematic Diagram of CRISPR Knockout. (BioVenic Original)

Featured CRISPR Services in Precision Animal Breeding

CRISPR Target Design

According to the target gene or gene fragments you want to edit, BioVenic provides efficient and comprehensive CRISPR knockout design for animal genomes, including the design of sgRNA and homology arms for the target gene, as well as the construction of gRNA and plasmids.

sgRNA Synthesis

For different sites in the genome, sgRNA varies the sequence for each target. High-quality sgRNAs are the foundation of the successful gene editing process. BioVenic provides you with a large amount of sgRNA synthesized by in vitro transcription. We also offer other CRISPR gRNA services for precision animal breeding research.

CRISPR Knockout Vector Construction

CRISPR genome editing in animal cells needs to be mediated by tool plasmid vectors. The careful design of knockout tool plasmids ensures more stable and accurate knockout effects. BioVenic offers customized services for constructing CRISPR knockout vectors capable of stably and efficiently editing animal genomes.

CRISPR Gene Knockout

We offer comprehensive single-gene and multi-gene knockout programs, which include designing tools of genome editing sites, targeting knockout, and verifying the sequencing. BioVenic delivers high-quality results while maintaining efficiency through the collaboration of the animal genome editing research group and the project planning team.

CRISPR sgRNA Library Construction

High-throughput genetic screening is of vital importance for the discovery of key targets in precision animal breeding research. BioVenic provides one-stop gene function screening services based on CRISPR sgRNA libraries. With professional platforms and mature technologies, sgRNA library construction service can be achieved efficiently.

Fig.2 CRISPR Knockout Methodolog (BioVenic Authorized)

Applications of Gene Knockout in Animal Breeding

With the development of gene editing technology, precise animal breeding guided by gene editing has broken through the bottleneck of traditional breeding and ushered in a new era of animal breeding. Scientists have successfully bred disease-resistant livestock, including pigs resistant to PRRSV, cattle resistant to Mycobacterium, chickens resistant to ALV, etc. and through editing gene targets related to productivity and welfare, novel lines of animals with valuable phenotypes can be generated that improve animal health and welfare as well as enhance animal growth and production. Discovering the target of gene editing is the primary focus of advancing the entire technology, which can also be achieved through gene editing technology itself.

Why Choose Us?

Genome knockout technology more suitable for farmed animals.

Accurate knockout of target genes without unexpected mutations.

An expert team of animal genome editing that provides technical support and assistance.

BioVenic has a team of skilled technical experts in CRISPR knockout in the research of precision animal breeding and an advanced technology platform to provide you with comprehensive support and assistance, then escorts your scientific research projects. If you are interested in any of our services, please do not hesitate to contact us for price inquiry.

Reference

Wang S., et al. Application of Gene Editing Technology in Resistance Breeding of Livestock. Life (Basel, Switzerland). 12,7 1070. 18 Jul. 2022